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E88 Other and unspecified metabolic disorders

ICD-10-CM category E88 sits in Chapter 4 (Endocrine, nutritional and metabolic diseases, E00-E89). It contains 24 billable codes for FY2027, effective October 1, 2026 to September 30, 2027. Always code to the most specific code available: a code with more characters that describes the diagnosis more precisely takes priority over a shorter one.

Subcategories

E88.0 Disorders of plasma-protein metabolism, NECE88.1 Lipodystrophy, not elsewhere classifiedE88.4 Mitochondrial metabolism disordersE88.8 Other specified metabolic disordersE88.81 Metabolic syndrome and other insulin resistance

Billable codes in E88

CodeDescription
E88.01Alpha-1-antitrypsin deficiency
E88.02Plasminogen deficiency
E88.09Other disorders of plasma-protein metabolism, not elsewhere classified
E88.10Lipodystrophy, unspecified
E88.11Partial lipodystrophy
E88.12Generalized lipodystrophy
E88.13Localized lipodystrophy
E88.14HIV-associated lipodystrophy
E88.19Other lipodystrophy, not elsewhere classified
E88.2Lipomatosis, not elsewhere classified
E88.3Tumor lysis syndrome
E88.40Mitochondrial metabolism disorder, unspecified
E88.41MELAS syndrome
E88.42MERRF syndrome
E88.43Disorders of mitochondrial tRNA synthetases
E88.49Other mitochondrial metabolism disorders
E88.810Metabolic syndrome
E88.811Insulin resistance syndrome, Type A
E88.818Other insulin resistance
E88.819Insulin resistance, unspecified
E88.82Obesity due to disruption of MC4R pathway
E88.89Other specified metabolic disorders
E88.9Metabolic disorder, unspecified
E88.AWasting disease (syndrome) due to underlying condition

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